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Researchers examine how KPV blocks the nuclear translocation of Nuclear Factor kappa B (NF-$\kappa$B) in both intestinal epithelial cells and active immune cells, subsequently shutting down the transcription and downstream secretion of damaging pro-inflammatory cytokines such as TNF-$\alpha$, IL-1$\beta$, and IL-6

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The incidence of adverse effects, particularly gastrointestinal complications, psychiatric disorders, and ocular problems, highlights the critical need for thorough patient assessment and continuous monitoring to ensure both the safety and effectiveness of treatment

TB-500 regulates cytoskeletal dynamics and cell motility